Serum uric acid/creatinine ratio and 1-year stroke recurrence in patient with acute ischemic stroke and abnormal renal function: results from the Xi'an stroke registry study of China.

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Tác giả: Qiaoqiao Chang, Weiyan Guo, Yunlong Hao, Zhen Lei, Xuemei Lin, Pei Liu, Tong Liu, Zhongzhong Liu, Qingli Lu, Linna Peng, Fang Wang, Songdi Wu, Lingxia Zeng, Dandan Zhang, Mi Zhang

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: Switzerland : Frontiers in neurology , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 213513

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BACKGROUND: The relationship between abnormal renal function and serum uric acid levels in patients with acute ischemic stroke (AIS) remains insufficiently explored. Although uric acid is associated with cardiovascular and cerebrovascular risk, the specific link between normalized serum uric acid (SUA/SCr) and stroke recurrence in patients with impaired renal function has not been well studied. This study aims to fill this gap by investigating the association between SUA/SCr and 1-year stroke recurrence in patients with AIS and abnormal renal function. METHODS: This study utilized the ratio of serum uric acid (SUA) to serum creatinine (SCr) to represent SUA levels normalized for renal function. Abnormal Renal function was defined by the estimated glomerular filtration rate (eGFR) <
90 mL/min/1.73 m RESULTS: Of 1,932 enrolled patients (65.3% male
mean age 66.7 ± 11.3 years), each unit of increase in SUA/SCr was associated with a 17% decrease in 1-year stroke recurrence (HR = 0.83, 95% CI 0.73 to 0.96, CONCLUSION: Low SUA/SCr independently predicts 1-year stroke recurrence in patients with AIS and abnormal renal function, particularly in those with eGFR <
60 mL/min/1.73 m

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