Sickle Cell Disease (SCD) poses a significant healthcare challenge in Kenya, with about 14,000 new cases annually. Fragmented data collection hampers patient management, research, and resource allocation. This paper proposes a framework for a centralized SCD registry in Kenya, integrating with existing systems like KenyaEMR. Through stakeholder engagement and systematic design, we outline methods, system design, implementation strategies, and success metrics. The solution aims to enhance patient care, support research, and inform policy development.