Polysulfone Membrane Embedded With Chiral Condensation Product: A Dual Approach of Experimental Validation and Theoretical Prediction for Enantiomeric Separation of Racemic Alanine.

• Tác giả: Monti Gogoi, Rajiv Goswami, Swapnali Hazarika
• Ngôn ngữ: eng
• Thông tin xuất bản: England : Biomedical chromatography : BMC , 2025
• Bộ sưu tập: NCBI
• ID: 213840

Tóm tắt

The precise separation of enantiomers is crucial in the pharmaceutical industry for the production of single enantiomer drugs. In this study, a novel chiral composite membrane was developed by embedding L-alanine glutaraldehyde condensation product (L-AGCP) onto a polysulfone (PSf) matrix for enantioselective separation. The PSf-L-AGCP membranes were systematically characterized using spectroscopic techniques to confirm the successful incorporation of L-AGCP and to evaluate the structural properties. Permeation studies using DL-alanine demonstrated that the membrane achieved an enantiomeric excess (ee) of 94% for D-alanine, with a flux of 68.1 mmol·m