Magnetic Resonance-Guided Focused Ultrasound Treatment for Essential Tremor: A Single-Center Experience.

• Tác giả: Anne Sofie Møller Andersen, Lone Andersen, Martin Andreasen, Ida Baandrup, Lisa Østergaard Bak, Birgitte Barrutia, Bo Bergholt, Jette Bjørn, Charlotte Bræmer-Madsen, Erik Hvid Danielsen, Christian Fenger Eriksen, Winnie Bechmann Eriksen, Michael Geneser, Andreas Nørgaard Glud, Dora Grauballe, Victor S Hvingelby, Bo Jespersen, Erik Lisbjerg Johnsen, Signe Mygdal Jørgensen, Niels Juhl, Pernille Kjeldsen, Mette Kromann, Torben Ellegaard Lund, Skirmante Mardosiene, Kaare Meier, Mette Møller, Mads Rasmussen, Gaston Andres Schechtmann, Jens Christian Hedemann Sørensen, Tina Vincens Sørensen, Rie Stjernholm, Alp Tankisi
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Movement disorders clinical practice , 2025
• Bộ sưu tập: NCBI
• ID: 213893

Tóm tắt

 BACKGROUND: Essential tremor is the most common hyperkinetic movement disorder. Magnetic resonance imaging-guided focused ultrasound (MRgFUS) has emerged as second-line therapy. OBJECTIVE: The aim was to obtain the results of the first 108 patients treated with MRgFUS in Denmark. METHODS: Data were entered in a quality assurance database at baseline and 3, 6, and 12 months. Clinician- and patient-rated treatment efficacy was evaluated using the Fahn-Marin-Tolosa (FMT) scale and the Patient Global Impression of Change. RESULTS: A total of 108 persons have currently been treated. Tremor improved by a total mean 6.39 points (95% confidence interval [CI]: 5.01
 7.76, P <
  0.00001) and 9.63 points (95% CI: 7.60
 11.66, P <
  0.00001), 10.42 (95% CI: 9.06
 11.79, P <
  0.00001), and 26.45 (95% CI: 22.46
 30.43, P <
  0.00001) for FMT parts A, B, and C, respectively, at 3 months. Side effects occurred in 65.7% of patients at 3 months and 33.7% at 12 months. CONCLUSION: Our findings are in line with existing evidence. Questions regarding persistence of gait- and balance-related side effects remain.