Indonesia, recognized as the world's second-largest mega-biodiversity country, is home to a remarkable variety of endemic species, including the iconic Birds of Paradise. Despite its rich biodiversity, the population of Birds of Paradise in Papua, Indonesia, is critically threatened by factors such as habitat loss, hunting, and exploitation. This systematic literature review aims to identify and synthesize the key reasons behind the conservation of these birds and evaluate current conservation strategies. Utilizing the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines, 354 articles were screened from databases, including Scopus, Web of Science, and Google Scholar, with 39 articles meeting the inclusion criteria. The review highlights that habitat destruction, introduced species, and unsustainable hunting practices are the primary threats to these species. The novelty of this study lies in its comprehensive synthesis of biological, ecological, and socio-cultural factors influencing the conservation of Birds of Paradise in Papua, as well as the evaluation of advanced genetic technologies as potential conservation strategies. The findings underscore the urgent need for enhanced conservation measures, including the development of advanced genetic technologies and community-driven efforts, to preserve the unique biodiversity of Papua's Birds of Paradise.