Air Pollution Associated With Mortality Among Chronic Hepatitis B Patients Treated With Nucleotide/Nucleoside Analogues.

• Tác giả: Pau-Chung Chen, Ya-Yun Cheng, Wan-Long Chuang, Chia-Yen Dai, Meng-Hsuan Hsieh, Ming-Yen Hsieh, Chung-Feng Huang, Jee-Fu Huang, Tyng-Yuan Jang, Po-Cheng Liang, Yi-Hung Lin, Pei-Chien Tsai, Chih-Wen Wang, Yu-Ju Wei, Chih-Da Wu, Jeng-Fu Yang, Ming-Lun Yeh, Ming-Lung Yu, Yu-Ting Zeng
• Ngôn ngữ: eng
• Ký hiệu phân loại: 972.92033 *West Indies (Antilles) and Bermuda
• Thông tin xuất bản: England : Alimentary pharmacology & therapeutics , 2025
• Bộ sưu tập: NCBI
• ID: 214167

Tóm tắt

 BACKGROUND AND AIMS: Air pollution is associated with advanced liver fibrosis in patients with chronic liver diseases, including chronic hepatitis B (CHB). This study aimed to investigate the association between air pollution and mortality in patients with CHB treated with nucleotide/nucleoside analogues. METHODS: We enrolled 697 patients with CHB treated with nucleotide/nucleoside analogues and analysed the incidence and risk factors for mortality. Daily air pollutant concentrations were estimated from the year before enrolment. RESULTS: All-cause mortality showed an annual incidence of 1.1/100 person-years after a follow-up period of 3798.1 person-years. Factors with the strongest association with all-cause mortality were liver cirrhosis (hazard ratio [HR]/95% confidence interval [CI]: 3.95/1.69-9.23
  p = 0.02), age ([HR]/CI: 1.07/1.03-1.17, p <
  0.001) and pre-treatment gamma-glutamyl transferase (GGT) levels (HR/CI: 1.004/1.001-1.006, p = 0.004). Among patients with cirrhosis, the factors associated with all-cause mortality were age (HR/CI: 1.08/1.04-1.12, p <
  0.001), pre-treatment GGT levels (HR/CI: 1.004/1.001-1.008, p = 0.01), platelet count (HR/CI: 0.988/0.977-0.998, p = 0.02) and NO CONCLUSIONS: Air pollution influences all-cause mortality in patients with CHB receiving nucleotide/nucleoside analogue therapy. Long-term NO