Tinidazole vs metronidazole for the treatment of bacterial vaginosis: a systematic review and meta-analysis.

• Tác giả: Lubna Al-Sharif, Fernando Augusto Barreiros, Marina Ayabe Gomes de Moraes, Hilária Saugo Faria, João Lucas de Magalhães Leal Moreira, Maria Julia Gonzaga Pascoalin, Clara de Andrade Pontual Peres, Livia Kneipp Rodrigues, Victor Gonçalves Soares, Milene Vitória Sampaio Sobral
• Ngôn ngữ: eng
• Thông tin xuất bản: Germany : Archives of gynecology and obstetrics , 2025
• Bộ sưu tập: NCBI
• ID: 214419

Tóm tắt

 INTRODUCTION: Tinidazole shows potential as a first-line treatment for bacterial vaginosis (BV). However, its superiority to metronidazole remains uncertain. Therefore, this meta-analysis compares tinidazole versus metronidazole in patients with BV. METHODS: We systematically searched PubMed, Embase and Cochrane for studies comparing tinidazole and metronidazole in patients with BV. Statistical analyses were performed using R Studio 4.3.2. Heterogeneity was examined with the Cochran Q test and I RESULTS: Five randomized controlled trials and 1 prospective observational study, reporting data on 1,036 patients were included in this meta-analysis. Among them, 511 (49%) received tinidazole and 525 (51%) received metronidazole. Follow-up ranged from 1 to 6 weeks. There was no significant difference between groups for BV cure at the first follow-up appointment (RR 1.03
  95% CI 0.92 to 1.14
  I CONCLUSION: In patients with BV, tinidazole and metronidazole exhibit similar efficacy and safety, with equivalent cure rates and incidence of adverse events.