Antimicrobial photodynamic therapy using gold nanoparticles conjugated with 1,9-dimethyl-methylene blue for treating Staphylococcus skin infections.

• Tác giả: Anildo Alves de Brito Júnior, Antonio Luiz Barbosa Pinheiro, Andressa Vollono Barbosa, Pedro Jorge Louro Crugeira, Juliana Monteiro Azevedo, Jean Nunes Dos Santos, Susana Carla Pires Sampaio de Oliveira, Wellington Luis Reis Costa, Maria Cristina Teixeira Cangussu
• Ngôn ngữ: eng
• Ký hiệu phân loại: 627.12 Rivers and streams
• Thông tin xuất bản: England : Lasers in medical science , 2025
• Bộ sưu tập: NCBI
• ID: 214449

Tóm tắt

This study aims to assess the effectiveness of Antimicrobial Photodynamic Therapy (aPDT) using phenothiazine photosensitizer (PS) combined with gold nanoparticles (DMMB-AuNPs) in treating S. aureus-contaminated wounds on the dorsum of rats. Twelve Wistar rats were divided into four groups: Control, LED, DMMB-AuNPs, and DMMB-AuNPs + LED. DMMB-AuNPs were prepared using DMMB (300 ng/mL) and 5 nm diameter AuNPs (~ 5.5E + 13 particles/mL). The light source was a red LED (12 J/cm