Dysphagia in Parkinson´s disease. A 5-year follow-up study.

• Tác giả: Maria G Alonso Losada, Ruben Alonso Redondo, María Álvarez Sauco, Maria A Ávila Rivera, Carmen Borrué, Nuria Caballol, Iria Cabo, Marina Cosgaya, Esther Cubo, Teresa de Deus Fonticoba, Julio Dotor García-Soto, Sonia Escalante, Juan García Caldentey, Itziar Gastón, Víctor Gómez Mayordomo, Isabel González Aramburu, Jorge Hernández Vara, Silvia Jesús, Jaime Kulisevsky, Ines Legarda, Nuria López Ariztegui, Lydia López Manzanares, Pablo Martinez-Martin, Darrian McAfee, Zebenzui Mendoza, Manuel Menéndez-González, Pablo Mir, Víctor Nogueira, Carlos Ordás, Isabel Pareés, Pilar Sánchez Alonso, Diego Santos-García, Manuel Seijo, Berta Solano Vila, Caridad Valero, Lydia Vela
• Ngôn ngữ: eng
• Ký hiệu phân loại: 616.833 *Parkinson disease
• Thông tin xuất bản: Italy : Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology , 2025
• Bộ sưu tập: NCBI
• ID: 214727

Tóm tắt

 BACKGROUND AND OBJECTIVE: Dysphagia at time of diagnosis suggests atypical parkinsonism instead Parkinson´s disease (PD). Our aim was to analyze the frequency of dysphagia in patients with early PD comparing with a control group and to identify related factors. PATIENTS AND METHODS: Patients with early PD (≤ 2 years from symptoms onset) who were recruited from January/2016 to November/2017 (baseline visit
  V0) and evaluated annually for 5 years from the Spanish cohort COPPADIS were included in this prospective study. Controls were assessed at baseline and at 2-, 4-, and 5-year follow-up. Dysphagia was defined as a score ≥ 1 in the item 20 of the Non-Motor Symptoms Scale (NMSS). RESULTS: Dysphagia was more frequent at baseline in PD patients (19.6% [36/184]
  62.3 ± 8.3 years old
  56.8% males) than in controls (5.3% [11/206]
  60.9 ± 8.3 years old
  50% males) (p <
  0.0001) and in all visits as well (p <
  0.0001). A worse quality of sleep (Parkinson´s Disease Sleep Scale
  OR = 0.974
  p = 0.005), a greater impulse-control behavior (ICB) (Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale
  OR = 1.066
  p = 0.014), and non-motor symptoms burden (Non-Motor Symptoms Scale
  OR = 1.016
  p = 0.021) were independent factors associated with dysphagia at baseline. In those subjects with dysphagia, no differences were observed between patients and controls in the mean NMSS-item 20 overtime, and it didn´t change throughout the follow-up. CONCLUSION: Dysphagia was frequent in early PD patients compared to controls. However, it was minor and did not progress over time. Sleep, ICB, and non-motor symptoms burden were related to dysphagia.