Luteolin-Manganese Nanozyme Induces Apoptosis and Ferroptosis for Enhanced Cancer Therapy.

• Tác giả: Changfang Lu, Hui Wang, Xianxiang Wang, Aimin Wu, Gang Xiang, Siyuan Yu
• Ngôn ngữ: eng
• Ký hiệu phân loại: 553.462 Titanium, vanadium, manganese
• Thông tin xuất bản: United States : Inorganic chemistry , 2025
• Bộ sưu tập: NCBI
• ID: 214781

Tóm tắt

Cancer presents a significant global public health challenge that impacts millions of individuals worldwide. The incorporation of natural products into cancer treatment has the potential to mitigate many of the side effects commonly associated with chemotherapy. This study builds on the advantages of enhancing the anticancer activity of natural flavonoids through metal chelation by synthesizing a natural antioxidant flavonoid complex, termed Lu-Mn nanozyme, which involves the chelation of luteolin with manganese ions. In vitro experiments demonstrated that Lu-Mn exhibits a strong affinity for hydrogen peroxide (H