Intracellular diffusion in the cytoplasm increases with cell size in fission yeast.

• Tác giả: Fred Chang, Michael C Lanz, Jan Skotheim, Matthew Swaffer, Catherine Tan
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Molecular biology of the cell , 2025
• Bộ sưu tập: NCBI
• ID: 214832

Tóm tắt

Diffusion in the cytoplasm can greatly impact cellular processes, yet regulation of macromolecular diffusion remains poorly understood. There is increasing evidence that cell size affects the density and macromolecular composition of the cytoplasm. Here, we studied whether cell size affects diffusion at the scale of macromolecules tens of microns in diameter. We analyzed the diffusive motions of intracellular genetically-encoded multimeric 40 nm nanoparticles (cytGEMs) in the cytoplasm of the fission yeast