Human milk (HM) research has its origins in the early 20th century, emerging from the field of dairy science. Early pioneers such as Drs. David Forsyth, Lucy Naish, and Disney Cran were among the first to formally study HM, building on centuries of recognition of its importance. Clinicians such as Dr. Ruth A. Lawrence, a true "giant" in the field, played a pivotal role in translating HM research into medical education and clinical practice. This commentary highlights the milestones, key contributors, technical advancements, and future directions of HM research, tracing its journey from modest beginnings to its establishment as a rapidly evolving scientific discipline.