Predicting outcomes in persistent atrial fibrillation: the impact of surface ECG f-wave amplitude following pulmonary vein isolation.

• Tác giả: Ciro Ascione, Aruran Baskaralingam, Giulia Domenichini, Sven Knecht, Michael Kühne, Mathieu Le Bloa, Adrian Luca, Matteo Marchetti, Patrizio Pascale, Alessandra Pia Porretta, Etienne Pruvot, Laurent Roten, Jorge Solana-Munoz, Christian Sticherling, Cheryl Teres
• Ngôn ngữ: eng
• Ký hiệu phân loại: 305.568 +Alienated and excluded classes
• Thông tin xuất bản: Netherlands : Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing , 2025
• Bộ sưu tập: NCBI
• ID: 215112

Tóm tắt

BACKGROUND: Fibrillatory wave amplitude (fWA) on 12-lead ECG predicts the outcome of ablation in atrial fibrillation (AF). We hypothesized that changes in fWA following wide circumferential isolation of pulmonary veins (WPVI) in persistent AF (peAF) is a better predictor of ablation outcome compared to baseline fWA. METHODS: Eighty-nine patients (sustained peAF 7 ± 7 months) underwent a first-time WPVI. Sixty-second ECG signals devoid of QRST waves were recorded at baseline and at the end of the WPVI (endWPVI). fWA for each ECG lead and mean fWA (meanfWA) across the 12-lead ECG were computed. Patients with recurrence after the index WPVI underwent a redo to ensure complete PVI. The primary endpoint was long-term AF freedom OFF antiarrhythmics drugs (AADs) after one or two WPVI (SUCCESS group). The FAILURE group was defined as AF recurrence post-redo. RESULTS: Over a mean follow-up of 35 ± 10 months, freedom from AF OFF AADs was achieved in 61% (SUCCESS group), while 29% had AF recurrence after redo WPVI (FAILURE group). The SUCCESS group showed significantly higher fWA values in ECG leads V CONCLUSION: Low fWA values and a significant reduction in fWA following WPVI are associated with a high risk of AF recurrence in patients with peAF.