Dissecting the metabolic signaling pathways by which microbial molecules drive the differentiation of regulatory B cells.

• Tác giả: Isabelle Bekeredjian-Ding, Stephan Göttig, Nora Kappelhoff, Felix F Krause, Hanna Leister, Maik Luu, Lisa Mainieri, Kira Mangold, Heide Monning, Carlos Plaza-Sirvent, Ingo Schmitz, Leon N Schulte, Yoav D Shaul, Sarah Staudt, Ulrich Steinhoff, Alexander Visekruna, Anne Wempe, Kai Ziegler-Martin
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Mucosal immunology , 2025
• Bộ sưu tập: NCBI
• ID: 215306

Tóm tắt

The host-microbiome axis has been implicated in promoting anti-inflammatory immune responses. Yet, the underlying molecular mechanisms of commensal-mediated IL-10 production by regulatory B cells (Bregs) are not fully elucidated. Here, we demonstrate that bacterial CpG motifs trigger the signaling downstream of TLR9 promoting IκB