Cis-Regulatory Element and Transcription Factor Circuitry Required for Cell-Type Specific Expression of FOXP3.

• Tác giả: Maya M Arce, Julia A Belk, Howard Y Chang, Jacob E Corn, Gemma L Curie, Rama Dajani, Jacob W Freimer, Luke A Gilbert, Laine Goudy, Benjamin G Gowen, Rosmely Hernandez, Sivakanthan Kasinathan, Nikhita Kirthivasan, Zhongmei Li, Alexander Marson, Cody T Mowery, Vinh Nguyen, Mineto Ota, Katherine S Pollard, Ansuman T Satpathy, Dimitre R Simeonov, Sanjana Subramanya, Carinna Tran, Jennifer M Umhoefer, Sean Whalen, Wenxi Zhang, Royce Zhou
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : bioRxiv : the preprint server for biology , 2025
• Bộ sưu tập: NCBI
• ID: 215316

Tóm tắt

FOXP3 is a lineage-defining transcription factor (TF) for immune-suppressive regulatory T cells (Tregs). While mice exclusively express FOXP3 in Tregs, humans also transiently express FOXP3 in stimulated conventional CD4+ T cells (Tconvs). Mechanisms governing these distinct expression patterns remain unknown. Here, we performed CRISPR screens tiling the