Deceased donor urinary Dickkopf-3 associates with future allograft function following kidney transplantation.

• Tác giả: Kerstin Amann, Anette Bachmann, Ronald Biemann, Klemens Budde, Martin Busch, Christoph Daniel, Katalin Dittrich, Christoph Engel, Jonathan de Fallois, Matthias Girndt, Anna Günzel, Jan Halbritter, Elena Hantmann, Christian Hugo, Berend Isermann, Tom H Lindner, Alexander Paliege, Ulrich Pein, Felix Pfeifer, Daniel Seehofer, Julian Stumpf, Antje Weimann, Thorsten Wiech, Gunter Wolf
• Ngôn ngữ: eng
• Ký hiệu phân loại: 577.23 *Seasons
• Thông tin xuất bản: United States : American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons , 2025
• Bộ sưu tập: NCBI
• ID: 215341

Tóm tắt

 Predicting future kidney allograft function is challenging. Novel biomarkers, such as urinary Dickkopf-3 (uDKK3), may help guide donor selection and improve allograft outcomes. In this prospective multicenter pilot trial, we investigated whether donor uDKK3 reflects organ quality and is associated with future allograft function. We measured uDKK3/crea ratios (uDKK3/crea) from 95 deceased and 46 living kidney donors. Prenephrectomy uDKK3/crea levels were 100× higher in deceased than in living donors (9888 pg/mg vs 113 pg/mg
  P <
  .001). Among deceased donor transplantations, recipients were stratified by their corresponding uDKK3/crea donor levels ranging below (group A, n = 68) or above (group B, n = 65) median. The primary end point of best estimated glomerular filtration rate (eGFR) within the first 3 months after kidney transplantation was superior in group A (56.3 mL/min/1.73 m