ATP6V1D drives hepatocellular carcinoma stemness and progression via both lysosome acidification-dependent and -independent mechanisms.

• Tác giả: Haoying Ke, Ruiyang Liu, Fei Xiao, Fuyuan Xu, Zhijie Xu, Pengfei Yang, Yi Zhan, Weiyu Zhang, Zhiju Zhao
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Autophagy , 2025
• Bộ sưu tập: NCBI
• ID: 215360

Tóm tắt

Metabolic reprogramming is pivotal in cancer stem cell (CSC) self-renewal. However, the intricate regulatory mechanisms governing the crosstalk between metabolic reprogramming and liver CSCs remain elusive. Here, using a metabolic CRISPR-Cas9 knockout screen, we identify ATP6V1D, a subunit of the vacuolar-type H