Multi-ancestry GWAS reveals loci linked to human variation in LINE-1- and Alu-insertion numbers.

• Tác giả: Bérénice A Benayoun, Juan I Bravo, Lucia Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 627.12 Rivers and streams
• Thông tin xuất bản: United States : bioRxiv : the preprint server for biology , 2025
• Bộ sưu tập: NCBI
• ID: 215363

Tóm tắt

LINE-1 (L1) and Alu are two families of transposable elements (TEs) occupying ~17% and ~11% of the human genome, respectively. Though only a small fraction of L1 copies is able to produce the machinery to mobilize autonomously, Alu and degenerate L1s can hijack their functional machinery and mobilize