Transferrin receptor targeting chimeras for membrane protein degradation.

• Tác giả: Garyk Brixi, Jhoely Duque-Jimenez, Francesco Facchinetti, William W Feng, Pasi A Jänne, Kaitlin Rhee, Dingpeng Zhang, Xin Zhou
• Ngôn ngữ: eng
• Ký hiệu phân loại: 384.5545 Wireless communication
• Thông tin xuất bản: England : Nature , 2025
• Bộ sưu tập: NCBI
• ID: 215377

Tóm tắt

Cancer cells require high levels of iron for rapid proliferation, leading to significant upregulation of cell-surface transferrin receptor 1 (TfR1), which mediates iron uptake by binding to the iron-carrying protein transferrin