CSF1-dependent macrophage support matrisome and epithelial stress-induced keratin remodeling in Eosinophilic esophagitis.

• Tác giả: Rachel Andrews, Taylor M Benson, Jennifer O Black, Cassandra Burger, Kelley E Capocelli, Louise Crowe, Taylor Crue, Monika Dzieciatkowska, Glenn T Furuta, Juliet A Hammer, Kimberly R Jordan, Gary E Markey, Joanne C Masterson, Eóin N McNamee, Calies Menard-Katcher, Sinéad Ryan, Kathleen M Scullion, Luke Simerly
• Ngôn ngữ: eng
• Ký hiệu phân loại: 720.286 Remodeling
• Thông tin xuất bản: United States : Mucosal immunology , 2025
• Bộ sưu tập: NCBI
• ID: 215405

Tóm tắt

Atopic diseases such as Eosinophilic Esophagitis (EoE) often progress into fibrosis (FS-EoE), compromising organ function with limited targeted treatment options. Mechanistic understanding of FS-EoE progression is confounded by the lack of preclinical models and the heavy focus of research on eosinophils themselves. We found that macrophage accumulation precedes esophageal fibrosis in FS-EoE patients. We developed a FS-EoE model via chronic administration of oxazalone allergen, in a transgenic mouse over-expressing esophageal epithelial hIL-5 (L2-IL5