Modulation of Stemness and Differentiation Regulators by Valproic Acid in Medulloblastoma Neurospheres.

• Tác giả: Algemir Lunardi Brunetto, André Tesainer Brunetto, Mariane da Cunha Jaeger, Matheus Dalmolin, Caroline Brunetto de Farias, Marcelo A C Fernandes, Natália Hogetop Freire, Lauro José Gregianin, Alice Laschuk Herlinger, Carolina Nör, Vijay Ramaswamy, Rafael Roesler, Michael D Taylor, Julia Vanini
• Ngôn ngữ: eng
• Ký hiệu phân loại: 661.22 Sulfuric acid
• Thông tin xuất bản: United States : bioRxiv : the preprint server for biology , 2025
• Bộ sưu tập: NCBI
• ID: 215467

Tóm tắt

Changes in epigenetic processes such as histone acetylation are proposed as key events influencing cancer cell function and the initiation and progression of pediatric brain tumors. Valproic acid (VPA) is an antiepileptic drug that acts partially by inhibiting histone deacetylases (HDACs) and could be repurposed as an epigenetic anticancer therapy. Here, we show that VPA reduced medulloblastoma (MB) cell viability and led to cell cycle arrest. These effects were accompanied by enhanced H3K9 histone acetylation (H3K9ac) and decreased expression of the