Environmental contexts likely influence the extent to which LGBTQIA+ individuals, compared to their cisgender, heterosexual counterparts, experience poorer physical, mental, and behavioral health outcomes. This case study was conducted within a non-affirming, religiously affiliated university. A Qualtrics-hosted survey was completed by 596 students, of whom 63% identified as White, 37% as BIPOC, and 36% as LGBTQIA+. We examined perceptions of LGBTQIA+ college non-responsiveness and LGBTQIA+ stigma as mediators between LGBTQIA+ identity and affective well-being, and the role of BIPOC identity as a moderator of this effect. Consistent with existing literature, LGBTQIA+ students reported lower affective well-being (B = -0.236,