Pro-inflammatory NK-like T cells are expanded in the blood and inflamed intestine in Crohn's disease.

• Tác giả: Friederike Berberich-Siebelt, Maike Büttner-Herold, Hyun-Dong Chang, Cristina M Chiarolla, Valeria Falcone, Sebastian Ferrara, Hartmut Hengel, Katja Hoffmann, Michael Lohoff, Henrik E Mei, Michael Meir, Martina Prelog, Simone Reu-Hofer, Addi J Romero-Olmedo, Andreas Rosenwald, Nicolas Schlegel, Axel R Schulz, Yin Xiao
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Mucosal immunology , 2025
• Bộ sưu tập: NCBI
• ID: 215828

Tóm tắt

Altered intestinal immune homeostasis leads to chronic inflammation in Crohn's disease (CD). To address disease- and tissue-specific alterations, we performed a T cell-centric mass cytometry analysis of peripheral and intestinal lymphocytes from patients with CD and healthy donors' PBMCs. Chronic intestinal inflammation enforced activation, exhaustion, and terminal differentiation of CD4