The C-type lectin receptor MINCLE interferes with eosinophil function and protective intestinal immunity in Strongyloides ratti-infected mice.

• Tác giả: Jennifer Antwi-Ekwuruke, Corinna Bang, Minka Breloer, Sara Dörken, Vinayaga Gnanapragassam, Wiebke Hartmann, Lennart Heepmann, Bernd Lepenies, Lara Linnemann, Malte Rühlemann, Jürgen Ruland, Annette Schlosser, Birte Viebrock, Saleh M Yunus
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Mucosal immunology , 2025
• Bộ sưu tập: NCBI
• ID: 216121

Tóm tắt

Strongyloides ratti is a helminth parasite that displays tissue-migrating and intestinal life stages. Myeloid C-type lectin receptors (CLRs) are pattern recognition receptors that recognize pathogen-derived ligands and initiate immune responses. To date, the role of CLRs in S. ratti infection has not been investigated. Here, we show that S. ratti-derived ligands are recognized by the CLR Macrophage inducible Ca