Glucose Abnormalities Detected by Continuous Glucose Monitoring in Very Old Adults With and Without Diabetes.

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Tác giả: Josef Coresh, Natalie R Daya, Justin B Echouffo-Tcheugui, Michael Fang, Elizabeth Selvin, Arielle Valint, Dan Wang, B Gwen Windham

Ngôn ngữ: eng

Ký hiệu phân loại: 155.63 Adults by sex

Thông tin xuất bản: United States : Diabetes care , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 216320

 OBJECTIVE: To characterize the prevalence of continuous glucose monitoring (CGM)-defined glucose abnormalities in a large, community-based population of very old adults (>
 75 years). RESEARCH DESIGN AND METHODS: A cross-sectional analysis of 1,150 older adults with and without diabetes who attended the Atherosclerosis Risk in Communities Study (2021-2022). Diabetes was based on a self-reported diagnosis of diabetes by a health care provider, use of diabetes medication, or a hemoglobin A1c (HbA1c) ≥6.5%. Prediabetes was defined as an HbA1c of 5.7% to <
 6.5% and normoglycemia as an HbA1c of <
 5.7%. We analyzed CGM metrics, including mean glucose, measures of hyperglycemia, and the coefficient of variation, by diabetes status. RESULTS: Of the 1,150 participants (mean age 83 years, 59% women, 26% who are Black), 35.1% had normoglycemia, 34.5% had prediabetes, and 30.4% had diabetes. The summary 24-h ambulatory glucose profile for participants with prediabetes was very similar to those with normoglycemia. No participants with normoglycemia or prediabetes had a CGM mean glucose >
 140 mg/dL, while 32.7% of participants with diabetes had a CGM mean glucose >
 140 mg/dL. CONCLUSIONS: In very old adults with normal or prediabetes HbA1c, hyperglycemia detected by CGM was rare. This suggests that HbA1c adequately captures the burden of hyperglycemia for most people in this population.
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