Immunomodulatory and anti-ovarian cancer effects of novel astragalus polysaccharide micelles loaded with podophyllotoxin.

• Tác giả: Rui-Bo Guo, Liang Kong, Xue-Tao Li, Mo Liu, Yang Liu, Jia-Hua Wang, Yang Yu, Juan Zang, Lu Zhang, Zi-Xu Zhang
• Ngôn ngữ: eng
• Thông tin xuất bản: Netherlands : International journal of biological macromolecules , 2025
• Bộ sưu tập: NCBI
• ID: 216433

Tóm tắt

Ovarian cancer, a highly lethal form of gynecological cancer globally, has witnessed notable advancements in its treatment through the integration of nanotechnology and immunotherapy. Here, we designed a novel astragalus polysaccharide vector (PDA), encapsulating podophyllotoxin (PPT), and modifying methotrexate (DSPE-PEG