Sulfonamide-Pyrazole derivatives as next-generation Cyclooxygenase-2 enzyme inhibitors: From molecular design to in vivo efficacy.

• Tác giả: Hatem A Abdel-Aziz, Mahmoud Abdelrahman Alkabbani, Sara T Al-Rashood, Marwa Alsulaimany, Faizah A Binjubair, Mahmoud A El Hassab, Wagdy M Eldehna, Mohamed K Elgohary, Mahmoud S Elkotamy, Hazem A Ghabbour
• Ngôn ngữ: eng
• Ký hiệu phân loại: 627.12 Rivers and streams
• Thông tin xuất bản: Netherlands : International journal of biological macromolecules , 2025
• Bộ sưu tập: NCBI
• ID: 216686

Tóm tắt

The current research focuses on the design and synthesis of celecoxib analogues incorporating sulphonamide and pyrazole moieties (4, 5, 6a-e, and 7a-f) with the aim of achieving a broad range of COX-2 selectivity in vitro. Among these, compounds 6b-d, 7a, 7e, and 7d exhibited potent inhibition, with IC