Long-term intake of Tamogi-take mushroom (Pleurotus cornucopiae) mitigates age-related cardiovascular dysfunction and extends healthy life expectancy.

 0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Momoka Cyuman, Hirotaka Fukami, Haruki Horiguchi, Kazutaka Ikeda, Tsuyoshi Kadomatsu, Yuya Kinoshita, Ryoko Kusaba, Eiji Matsunaga, Keishi Miyata, Jun Morinaga, Koichi Node, Yuichi Oike, Yusuke Okadome, Masaru Sato, Michio Sato, Taichi Sugizaki, Chitoku Toda, Daisuke Torigoe

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: England : npj aging , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 217063

Age-related declines in cardiac function and exercise tolerance interfere with healthy living and decrease healthy life expectancy in older individuals. Tamogi-take mushrooms (Pleurotus cornucopiae) are known to contain high levels of Ergothioneine (EGT), an antioxidant with potential health benefits. In this study, we assessed the possibility that long-term consumption of Tamogi-take mushrooms might attenuate age-related decline in cardiac and vascular endothelial function in mice. We found that long-term intake of Tamogi-take mushrooms significantly maintained cardiac and vascular endothelial function and improved exercise tolerance in mice. Long-term mushroom consumption also increased levels of Nrf2 (Nuclear factor E2-related factor 2) protein in heart tissues and increased translation of HO-1 (Heme Oxygenase 1) proteins, which have antioxidant effects in heart and aortic tissues. Finally, long-term Tamogi-take mushroom consumption inhibited ROS accumulation with aging and reduced expression of inflammatory biomarkers. We conclude that ingestion of Tamogi-take mushrooms could serve as a dietary intervention to promote cardiovascular health, support healthy aging and slow the progression of age-related diseases.
Tạo bộ sưu tập với mã QR

THƯ VIỆN - TRƯỜNG ĐẠI HỌC CÔNG NGHỆ TP.HCM

ĐT: (028) 36225755 | Email: tt.thuvien@hutech.edu.vn

Copyright @2024 THƯ VIỆN HUTECH