Multi-TACs: Targeting Solid Tumors with Multiple Immune Cell Co-engagers.

• Tác giả: Feng Lin, Yuxuan Zhang, Zijian Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 616.992 Tumors
• Thông tin xuất bản: United States : ACS chemical biology , 2025
• Bộ sưu tập: NCBI
• ID: 217084

Tóm tắt

Multiple immune components in the complex and heterogeneous tumor-immune microenvironment (TIME) work cooperatively to promote or impede cancer immunotherapy. Synergistically co-managing multiple immune cells with single agents for advanced antitumor immunity remains desirable but challenging. This In Focus article introduces a triple orthogonal linker (T-Linker)-based multimodal targeting chimera (Multi-TAC) platform, enabling the single-agent-mediated tumor-targeted co-engagement of multiple immune cell types within TIME for potentiated immunotherapy.