Generation of a KDM5D knockout human embryonic stem cell line with CRISPR/Cas9 technology.

• Tác giả: Ouhui Li, Qi Li, Yanlin Ma, Chao Sun, Luan Wen, Yuting Zhen
• Ngôn ngữ: eng
• Ký hiệu phân loại: 597.9598 Reptilia (Reptiles)
• Thông tin xuất bản: England : Stem cell research , 2025
• Bộ sưu tập: NCBI
• ID: 217096

Tóm tắt

KDM5D is a gene implicated in spermatogenic failure and sex-related differences in colon cancer progression, though its role in spermatogenesis remains unclear. We successfully generated a KDM5D knockout human embryonic stem cells using CRISPR/Cas9 technology. This knockout cell line provides a valuable model for studying KDM5D's function in spermatogenesis and its influence on sex differences in various diseases.