Fibrinogen is a common target of SVMP and SVSP. These toxins can destructively cleave fibrinogen, leading to the depletion of its levels. Herein we comparatively describe the fibrinogenolytic activity of the venom of Bothrops and Crotalus snakes, viperids of high epidemiological importance in Brazil. Results emphasize species-specific differences in the degradation rate and the specificity of the preferentially degraded fibrinogen chains, reflecting the complexity of the coagulotoxic effects induced by envenomation.