Generation of a PDK-1 knockout human embryonic stem cell line by CRISPR/(WAe009-A-2K) Cas9 editing.

• Tác giả: Muhammad Khawar Abbas, Jiaqi Fan, Hongfeng Jiang, Amina Saleem, Mingyu Wei, Yang Xian, Siyao Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 364.086949 Criminology
• Thông tin xuất bản: England : Stem cell research , 2025
• Bộ sưu tập: NCBI
• ID: 217153

Tóm tắt

Pyruvate Dehydrogenase Kinase1 (PDK1) belongs to the family of kinases, regulates diverse metabolic processes. PDK1 is a susceptibility locus for heart failure via thinning of ventricle walls, and enlarged atria and ventricles. We successfully developed a PDK1 knockout (PDK1