Development of a multi-functional naringin-loaded bioglass/carboxymethyl chitosan/silk fibroin porous scaffold for hemostasis and critical size bone regeneration.

• Tác giả: Lek Hang Cheang, Chia-Hsuan Chung, Zhaohui Dang, Botao Gao, Zefeng Lin, Yiwan Shi, Man Seng Tam, Huajun Wang, Zhaozhen Wang, Tingting Wu, Shan Yang, Xiaolu Yu, Xiaofei Zheng, Xinting Zhou
• Ngôn ngữ: eng
• Ký hiệu phân loại: 571.889 +Regeneration
• Thông tin xuất bản: Netherlands : International journal of biological macromolecules , 2025
• Bộ sưu tập: NCBI
• ID: 217517

Tóm tắt

Persistent bleeding and limited repair capacity greatly threaten patients with bone destruction. Designing inorganic-organic biomimetic scaffolds with quick hemostasis and osteogenesis functions will solve this problem. A novel degradable and naringin (NG) loaded porous scaffold (SCB-N) based on APTES-modified bioactive glass (ABG), carboxymethyl chitosan and silk fibroin is developed. ABG and NG enhance the strength of the scaffolds. The scaffolds can release NG and bioactive ions (Ca