Development of an

• Tác giả: Florent Allais, Flavio Ballante, Jens Carlsson, James Collins, Matthew T Eddy, Guillaume Ferré, Ivo Kabelka, Emma Mulry, Enzo Petracco, Arka P Ray
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : ACS chemical biology , 2025
• Bộ sưu tập: NCBI
• ID: 217529

Tóm tắt

Small molecules are essential for investigating the pharmacology of membrane proteins and remain the most common approach for therapeutically targeting them. However, most experimental small molecule screening methods require ligands containing radiolabels or fluorescent labels and often involve isolating proteins from their cellular environment. Additionally, most conventional screening methods are suited for identifying compounds with moderate to higher affinities (