Discovery of Dual ROCK1/2 Inhibitors from

• Tác giả: Thinh T M Bui, Hyeongju Jeong, Sang Hoon Jung, Suk Woo Kang, Hasun Kim, Hyejin Ko, Kyuho Moon, Dae-Geun Song, Soohyun Um
• Ngôn ngữ: eng
• Ký hiệu phân loại: 724 Architecture from 1400
• Thông tin xuất bản: United States : ACS chemical biology , 2025
• Bộ sưu tập: NCBI
• ID: 217945

Tóm tắt

Rho-associated protein kinase (ROCK) inhibitors are promising therapeutic agents for reducing elevated intraocular pressure in patients with glaucoma. We explored new ROCK inhibitors derived from bioactive metabolites produced by microbes, specifically cryptic metabolites from