Radical SAM Enzyme WprB Catalyzes Uniform Cross-Link Topology between Trp-C5 and Arg-Cγ on the Precursor Peptide.

• Tác giả: Stefano Donadio, Jabal Rahmat Haedar, Abujunaid Habib Khan, Vic Kiselov, Chin-Soon Phan, Viktors Romanuks, Gints Smits
• Ngôn ngữ: eng
• Ký hiệu phân loại: 296.1231 Sources
• Thông tin xuất bản: United States : ACS chemical biology , 2025
• Bộ sưu tập: NCBI
• ID: 217949

Tóm tắt

Cross-link containing products from ribosomally synthesized and post-translationally modified peptides (RiPPs) are generated by radical SAM enzymes (rSAM). Here, we bioinformatically expanded rSAM enzymes based on the known families StrB, NxxcB, WgkB, RrrB, TqqB and GggB. Through