The macular hole is a prevalent pathology whose types and causes are due to various reasons. Sometimes it can coexist with other diseases such as age-related macular degeneration. Its pathophysiological basis may have a common relationship with the degenerative lamellar foramen. Optical coherence tomography plays a fundamental role in understanding its genesis. In this work, we present the case of a 60-year-old patient with age-related macular degeneration, who consults due to decreased visual acuity in the left eye. The ophthalmological examination revealed a drusenoid detachment of the retinal pigment epithelium in the foveal area, visible by optical coherence tomography, in addition to multiple drusen in both eyes. Image follow-up showed regression of the detachment at the end of 60 days with the formation of a lamellar hole in its place. A follow-up was done for 24 months.