Genetically Defined Organoid Models Reveal Mechanisms Driving Squamous Cell Neoplastic Evolution and Identify Potential Therapeutic Vulnerabilities.

• Tác giả: Casey Collet, Boyan Hu, De-Chen Lin, Luda Lin, Qiong Mao, Anette Vistoro Monreal, Yuhao Pan, Young Min Park, Parish Sedghizadeh, Uttam K Sinha, Alice Soragni, Stephanie Wong, Hua Zhao, Yueyuan Zheng, Tianming Zhou
• Ngôn ngữ: eng
• Ký hiệu phân loại: 372.53 *Modeling and sculpture
• Thông tin xuất bản: United States : bioRxiv : the preprint server for biology , 2025
• Bộ sưu tập: NCBI
• ID: 217971

Tóm tắt

Upper aerodigestive squamous cell carcinoma (UASCC) is an aggressive and lethal neoplasm, with its early neoplastic transformation mechanisms remaining poorly understood. Here, we characterize over 25 genetically-defined organoid models derived from murine and human oral/esophageal tissues harboring key driver mutations. Double knockout of