CRISPR-Cas9 Cytidine-Base-Editor Mediated Continuous

• Tác giả: Donghui Guo, Qingbin Li, Yanling Li, Youchu Ma, Meng Pang, Yuan Tian, Lupeng Wang, Qing Xu, Dongfang Zhang, Zhiruo Zhang, Fanglong Zhao
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : ACS synthetic biology , 2025
• Bộ sưu tập: NCBI
• ID: 218007

Tóm tắt

Filamentous fungi are important cell factories for producing chemicals, organic acids, and enzymes. Although several genome editing tools are available for filamentous fungi, few effectively enable continuous evolution for rational engineering of complex phenotype. Here, we present CRISPR-Cas9 cytidine-base-editor (CBE) assisted