The liver clock tunes transcriptional rhythms in skeletal muscle to regulate mitochondrial function.

• Tác giả: Pierre Baldi, Pura Muñoz Cánoves, Siwei Chen, Sophia Hernandez, Kevin B Koronowski, Paolo Sassone-Corsi, Tomoki Sato, Valentina Sica, Jacob G Smith, Ioannis Tsialtas
• Ngôn ngữ: eng
• Ký hiệu phân loại: 133.594 Types or schools of astrology originating in or associated with a
• Thông tin xuất bản: United States : bioRxiv : the preprint server for biology , 2025
• Bộ sưu tập: NCBI
• ID: 218038

Tóm tắt

Circadian clocks present throughout the brain and body coordinate diverse physiological processes to support daily homeostasis and respond to changing environmental conditions. The local dependencies within the mammalian clock network are not well defined. We previously demonstrated that the skeletal muscle clock controls transcript oscillations of genes involved in fatty acid metabolism in the liver, yet whether the liver clock also regulates the muscle was unknown. Here, we use hepatocyte-specific