Histone deacetylase-1 is required for epigenome stability in

• Tác giả: Felicia Ebot-Ojong, Aileen R Ferraro, Clayton Hull-Crew, Farh Kaddar, Andrew D Klocko, Zachary A Lewis, Ashley W Scadden
• Ngôn ngữ: eng
• Ký hiệu phân loại: 796.343 Squash
• Thông tin xuất bản: United States : bioRxiv : the preprint server for biology , 2025
• Bộ sưu tập: NCBI
• ID: 218050

Tóm tắt

Polycomb group (PcG) proteins form chromatin modifying complexes that stably repress lineage- or context-specific genes in animals, plants, and some fungi. Polycomb Repressive Complex 2 (PRC2) catalyzes trimethylation of lysine 27 on histone H3 (H3K27me3) to assemble repressive chromatin. In the model fungus