CAR T-cell and oncolytic virus dynamics and determinants of combination therapy success for glioblastoma.

• Tác giả: Sergio Branciamore, Christine E Brown, Kevin A Cassady, Martina Conte, Russell C Rockne, Ryan T Woodall, Agata Xella
• Ngôn ngữ: eng
• Ký hiệu phân loại: 553.421 Silver
• Thông tin xuất bản: United States : bioRxiv : the preprint server for biology , 2025
• Bộ sưu tập: NCBI
• ID: 218061

Tóm tắt

Glioblastoma is a highly aggressive and treatment-resistant primary brain cancer. While chimeric antigen receptor (CAR) T-cell therapy has demonstrated promising results in targeting these tumors, it has not yet been curative. An innovative approach to improve CAR T-cell efficacy is to combine them with other immune modulating therapies. In this study, we investigate