A single dorsal vagal complex circuit mediates the aversive and anorectic responses to GLP1R agonists.

• Tác giả: Martin DeVaux, Shad Hassan, Stace Kernodle, Zitian Lin, Martin Myers, Tune Pers, Weiwei Qiu, Kirsten Raun, Alan Rupp, Frederike Sass, Anna Secher, Randy J Seeley, Abigail J Tomlinson, Yi Wang, Iris Wu, Warren T Yacawych, Guoxiang Zhou
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : bioRxiv : the preprint server for biology , 2025
• Bộ sưu tập: NCBI
• ID: 218087

Tóm tắt

GLP-1 receptor agonists (GLP1RAs) effectively reduce feeding to treat obesity, although nausea and other aversive side effects of these drugs can limit their use. Brainstem circuits that promote satiation and that mediate the physiologic control of body weight can be distinguished from those that cause aversion. It remains unclear whether brainstem