AIM2 targeting of nuclear DNA leakage in dendritic cells exacerbates vasculitis in a murine model of Kawasaki disease.

• Tác giả: Hidetoshi Aizawa, Chintogtokh Baatarjav, Yoshitaka Gunji, Tadayoshi Karasawa, Takanori Komada, Satoko Komori, Noriko Nagi-Miura, Masafumi Takahashi
• Ngôn ngữ: eng
• Ký hiệu phân loại: 333.92 Air
• Thông tin xuất bản: United States : American journal of physiology. Heart and circulatory physiology , 2025
• Bộ sưu tập: NCBI
• ID: 218230

Tóm tắt

Kawasaki disease (KD) is an acute vasculitis that mostly affects children and is characterized by inflammation of medium-sized arteries, particularly the coronary arteries. The absent in melanoma 2 (AIM2) inflammasome senses cytosolic dsDNA and regulates IL-1β-driven inflammation. We investigated the role of AIM2 in