Senescent macrophages trigger a pro-inflammatory program and promote the progression of rheumatoid arthritis.

• Tác giả: Wangwei Cai, Bocen Chen, Jiayao Chen, Tong Chen, Shaoqin Jian, Kongning Li, Yingjie Ma, Wenguang Wang, Man Xiao, Dahua Xu, Jing Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 320.9 Political situation and conditions
• Thông tin xuất bản: Netherlands : International immunopharmacology , 2025
• Bộ sưu tập: NCBI
• ID: 218249

Tóm tắt

This study explores the complex mechanisms between Rheumatoid Arthritis (RA) and cellular senescence, with a focus on the role of four key genes (MMP1, CCL7, CXCL1, HK3) identified through transcriptome analysis in the GEO database. These genes are closely related to IL-17 signalling and the pathogenesis of RA. In a macrophage senescence model induced by hydrogen peroxide (H