Hematophagous arthropods rely on taste mechanisms to navigate host selection, feeding, mating, and oviposition. These behaviors are driven by environmental taste cues, which shape acceptance or aversion depending on their valence. Positive stimuli, like low concentrations of salts, sugars, amino acids, and nucleotides, promote feeding and oviposition, while negative stimuli, including high salt, bitter compounds, and nociceptive chemicals, trigger avoidance to prevent hazards. Species-specific adaptations enable blood feeders to overcome ecological challenges. Understanding their behavioral, neuronal, and molecular taste mechanisms aids in developing targeted vector control strategies, such as repellents, toxic baits, and oviposition deterrents, to disrupt disease transmission.