Dearomative Alkylation of Heteroarenium Salts via Blue Light Enabled Homolytic C-C Bond Cleavage.

• Tác giả: Emma E Drake, Agshin Garayev, Rashad R Karimov, Evangelos Miliordos
• Ngôn ngữ: eng
• Ký hiệu phân loại: 661.4 Salts
• Thông tin xuất bản: United States : Organic letters , 2025
• Bộ sưu tập: NCBI
• ID: 218329

Tóm tắt

Alkyl substituted nitrogen heterocycles are important building blocks in drug molecules, agrochemicals, and materials. Herein we report a simple and efficient way to prepare such compounds by coupling alkyl halides with heteroarenium salts. Detailed experimental and computational studies indicate that this reaction goes through a radical coupling and avoids the formation of undesired homocoupling of heteroarenium salts via recycling such dimers through C-C bond cleavage under blue light.