Using Common Alcohols to Transform N-H NHC-Palladium Complexes into Reactive Catalysts for the Suzuki-Miyaura Reaction with Aryl Chlorides.

• Tác giả: Aimee L Bangerter, Lindsey M Brown, Caitlin C Chartrand, Rebecca J Cole, Alexis P Harper, Alexandra J S Larson, David J Michaelis, Daniel A Odogwu, Rachel N Owens, Sydney K F Pettit, Stacey J Smith
• Ngôn ngữ: eng
• Ký hiệu phân loại: 303.623 Riots
• Thông tin xuất bản: United States : The Journal of organic chemistry , 2025
• Bộ sưu tập: NCBI
• ID: 218350

Tóm tắt

We demonstrate that the generation of mixed NHC/phosphinite Pd catalysts from 2-phosphinoimidazole ligands using bulky alcohols provides highly active Pd catalysts for cross-coupling reactions. Mechanistic studies suggest that the rapid loss of bulkier phosphinites from the precatalyst leads to more rapid oxidative addition. These catalysts demonstrate a broad substrate scope in Suzuki-Miyaura reactions with aryl chlorides. Conversion of a methanol-derived catalyst into a