Pupillary unrest is attenuated in attention deficit hyperactivity disorder (ADHD).

• Tác giả: Samantha S Betts, Thom Carney, Stephen P Hinshaw, Sarah L Karalunas, Stanley A Klein, Agatha Lenartowicz, James T McCracken, Joel T Nigg, Sean Noah, Mercedes Oliva, Claudio M Privitera, Rory C Reid, Gregory V Simpson
• Ngôn ngữ: eng
• Ký hiệu phân loại: 616.8589 Diseases of nervous system and mental disorders
• Thông tin xuất bản: Ireland : Neuroscience letters , 2025
• Bộ sưu tập: NCBI
• ID: 218369

Tóm tắt

We investigated the phenomenon of pupillary unrest in individuals with Attention Deficit Hyperactivity Disorder (ADHD) compared to neurotypical controls. We measured the power of low-frequency pupil oscillations under two experimental conditions: a passive condition with minimal distraction and a resting condition with no distraction. The study included 76 adult participants (42 controls and 34 with ADHD) aged 18-40. The results show that individuals with ADHD exhibit reduced power in pupillary oscillations, suggesting a suppression of general catecholaminergic activity. The nature of the experiment indicates that this suppression is endemic in the background and independent of the visual task or the ongoing cognitive effort. This finding is consistent with our previous observations of reduced pupil dilations in ADHD during active tasks [1] and provide basic insights for future research aimed at developing and refining a psychophysical paradigm that could serve as a biomarker to enhance ADHD evaluation and classification.