Burning mouth syndrome (BMS) is a debilitating intraoral burning or dysesthesia sensation without any evident causative lesions on clinical examination and investigations. The etiopathogenesis of BMS remains uncertain, with proposed mechanisms including psychological, peripheral neuropathic, and central neuropathological factors. Management of BMS is generally symptomatic and often met with poor response. Published data on the successful pain management interventions are inadequate. This report describes the successful management of a 43-year-old patient with severe glossodynia, diagnosed as BMS, using ultrasound-guided suprazygomatic sphenopalatine ganglion block after poor response to the conventional therapies as well as stellate ganglion block.